What is the suggested treatment for membranoproliferative GN in the absence of infection, per the material?

• A. Steroids
• B. Antibiotics
• C. ACE inhibitors
• D. Observation only

Answer: (A)

Membranoproliferative GN without infection is treated by dampening the immune-driven inflammation in the glomeruli. Corticosteroids reduce the immune response, decrease mesangial proliferation, and lessen immune complex–mediated injury, which can translate into less protein leakage in the urine and stabilization or improvement of kidney function. Antibiotics are reserved for cases where an infectious trigger is present, since clearing infection addresses a different cause. While ACE inhibitors help control blood pressure and reduce proteinuria, they don’t treat the underlying inflammatory process, so they’re not the primary therapy in this scenario. Observation alone would miss active inflammation. Therefore, steroids are the best-supported treatment in the absence of infection.