Which of the following is NOT a typical feature of autosomal dominant polycystic kidney disease (ADPKD)?

• A. Hematuria
• B. Hypertension
• C. Pancreatic cancer
• D. Hepatic cysts

Answer: (C)

ADPKD commonly affects the kidneys with multiple cysts and often shows systemic features beyond the kidneys. Hematuria is frequent because cysts can bleed or rupture, and hypertension is very common due to increased renin production from the diseased kidneys, sometimes appearing before kidney function declines. The liver is also commonly involved, with hepatic cysts arising from the same cystic disease process. Pancreatic cancer, on the other hand, is not a typical or characteristic manifestation of ADPKD; pancreatic cysts can occur occasionally, but cancer is not a recognized feature of this condition.